Gut‐brain axis serotonergic responses to acute stress exposure are microbiome‐dependent
Abstract
Understanding the mechanisms underpinning the response to acute stress is critical for determining how this can be modulated in both health and disease and across sexes. Stress can markedly alter the microbiome and gut‐brain axis signaling with the serotonergic system being particularly sensitive to acute stress. As the impact of acute stress on regional serotonergic dynamics in the gut‐brain axis and the contribution of the microbiome to this are poorly appreciated, we used microbiota‐deficient mice to assess whether the serotonergic response to acute stress exposure is microbiome dependent.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 11, 2020
- Source ID
- 10.1111/nmo.13881
Entities
People
- Cassandra E. Gheorghe
- Gerard Clarke
- John F. Cryan
- Joshua M. Lyte
- Michael S Goodson
- Nancy Kelley‐loughnane
- Timothy G. Dinan
Organizations
- 711th Human Performance Wing
- Air Force Office of Scientific Research
- Science Foundation Ireland
- University College Cork