Identification of intrinsic primary afferent neurons in mouse jejunum
Abstract
The gut is the only organ system with intrinsic neural reflexes. Intrinsic primary afferent neurons (IPANs) of the enteric nervous system initiate intrinsic reflexes, form gut‐brain connections, and undergo considerable neuroplasticity to cause digestive diseases. They remain inaccessible to study in mice in the absence of a selective marker. Advillin is used as a marker for primary afferent neurons in dorsal root ganglia. The aim of this study was to test the hypothesis that advillin is expressed in IPANs of the mouse jejunum.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 28, 2020
- Source ID
- 10.1111/nmo.13989
Entities
People
- Alec M. Wright
- Arthur Beyder
- Carina Guimarães De Souza Melo
- Constanza Alcaino
- David R. Linden
- Evan N Nicolai
- Katie E. Miller
- Sara T. Whiteman
- Simon J Gibbons
- Tiffany J. Cassmann
Organizations
- Mayo Medical School
- National Institutes of Health
- United States Department of Defense