Experimental models of gut‐first Parkinson's disease: A systematic review
Abstract
There is strong support from studies in humans and in animal models that Parkinson's disease (PD) may begin in the gut. This brings about a unique opportunity for researchers in the field of neurogastroenterology to contribute to advancing the field and making contributions that could lead to the ability to diagnose and treat PD in the premotor stages. Lack of familiarity with some of the aspects of the experimental approaches used in these studies may present a barrier for neurogastroenterology researchers to enter the field. Much remains to be understood about intestinal‐specific components of gut‐first PD pathogenesis and the field would benefit from contributions of enteric and central nervous system neuroscientists.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 01, 2023
- Source ID
- 10.1111/nmo.14604
Entities
People
- Ashwaq Hamid Salem Yehya
- Elizabeth Videlock
- R A Travagli
- Tiaosi Xing
Organizations
- National Institutes of Health
- United States Department of Defense
- University of California, Los Angeles