Targeted protein degradation: from small molecules to complex organelles—a Keystone Symposia report
Abstract
Targeted protein degradation is critical for proper cellular function and development. Protein degradation pathways, such as the ubiquitin proteasomes system, autophagy, and endosome–lysosome pathway, must be tightly regulated to ensure proper elimination of misfolded and aggregated proteins and regulate changing protein levels during cellular differentiation, while ensuring that normal proteins remain unscathed. Protein degradation pathways have also garnered interest as a means to selectively eliminate target proteins that may be difficult to inhibit via other mechanisms. On June 7 and 8, 2021, several experts in protein degradation pathways met virtually for the Keystone eSymposium “Targeting protein degradation: from small molecules to complex organelles.” The event brought together researchers working in different protein degradation pathways in an effort to begin to develop a holistic, integrated vision of protein degradation that incorporates all the major pathways to understand how changes in them can lead to disease pathology and, alternatively, how they can be leveraged for novel therapeutics.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 08, 2022
- Source ID
- 10.1111/nyas.14745
Entities
People
- Alessio Reggio
- Anne Simonsen
- Brenda A. Schulman
- Carolyn R. Bertozzi
- Chunmei Chang
- Daniel J. Finley
- Della C. David
- Eilika Weber‐ban
- Eric J. Bennett
- Hong Zhang
- Ingrid E. Wertz
- Ivan Đikić
- J. Wade Harper
- Jennifer Cable
- John Hanna
- Jonathan M. Goodwin
- Judith Frydman
- Kylie J. Walters
- Liang Ge
- Malene Hansen
- Michal Sharon
- Mikołaj Słabicki
- Nicolas H. Thomä
- Raymond J. Deshaies
- Richa Sardana
- Sascha Martens
- Serena Carra
- Tim Clausen
- Ursula Jakob
- Vinay V. Eapen
- Yangnan Gu
- Yue Feng
Organizations
- Amgen
- Bristol-Myers Squibb
- Broad Institute
- Cornell University
- Dana–Farber Cancer Institute
- ETH Zurich
- Friedrich Miescher Institute for Biomedical Research
- Genentech
- German Cancer Research Center
- Harvard Medical School
- Max Planck Institute of Biochemistry
- Medical University of Vienna
- National Cancer Institute
- Oslo University Hospital
- Sanford Burnham Prebys Medical Discovery Institute
- Stanford Synchrotron Radiation Lightsource
- Stanford University
- Tsinghua University
- University of California, San Diego
- University of Chinese Academy of Sciences
- University of Michigan
- University of Modena and Reggio Emilia
- University of Oslo
- University of Toronto
- University of Tübingen
- University of Vienna
- Weizmann Institute of Science