Making a melanoma: Molecular and cellular changes underlying melanoma initiation
Abstract
Melanoma arises from the melanocyte lineage and is the most aggressive and lethal form of skin cancer. There are several genetic, genomic, and cellular changes associated with melanoma initiation. Here, we discuss these alterations and the melanoma cells of origin in which they are proposed to promote melanomagenesis.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 08, 2021
- Source ID
- 10.1111/pcmr.12950
Entities
People
- Craig J Ceol
- Revati Darp
Organizations
- United States Department of Defense
- University of Massachusetts Medical School