Neural correlates of N‐back task performance and proposal for corresponding neuromodulation targets in psychiatric and neurodevelopmental disorders
Abstract
Working memory (WM) deficit represents the most common cognitive impairment in psychiatric and neurodevelopmental disorders, making the identification of its neural substrates a crucial step towards the conceptualization of restorative interventions. We present a meta‐analysis focusing on neural activations associated with the most commonly used task to measure WM, the N‐back task, in patients with schizophrenia, depressive disorder, bipolar disorder, and attention‐deficit/hyperactivity disorder. Showing qualitative similarities and differences in WM processing between patients and healthy controls, we propose possible targets for cognitive enhancement approaches.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 28, 2022
- Source ID
- 10.1111/pcn.13442
Entities
People
- Emiliano Santarnecchi
- Giorgio Di Lorenzo
- Ilya Demchenko
- Lucia Mencarelli
- Sara M. Romanella
- Simone Rossi
- Venkat Bhat
Organizations
- Beth Israel Deaconess Medical Center
- Canadian Institutes of Health Research
- Defense Advanced Research Projects Agency
- Foundation for the National Institutes of Health
- Government of Canada
- Harvard Medical School
- Harvard University
- Intelligence Advanced Research Projects Activity
- Ministry of Health
- National Institutes of Health
- Office of the Director of National Intelligence
- Sapienza University of Rome
- St. Michael's Hospital
- University of Siena
- University of Toronto