Unrelated donor HLA re‐typing effort to verify prevalence of newer alleles: HLA‐A*24:23, A*30:10, DRB1*08:11, DRB1*15:03, and DRB1*15:06
Abstract
The National Marrow Donor Program (NMDP) is committed to maintaining accurate human leukocyte antigen (HLA) data for each of the 11.5 million volunteer donors on the Be The Match Registry®. Qualitative data analysis identified five population specific alleles suspect of being incorrectly characterized. Alleles evaluated were HLA‐A*24:03 for the presence of A*24:23 in Native Americans, A*30:02 for the presence of A*30:10 when B*41 and DRB1*04:05 were in the haplotype, DRB1*08:02 for the presence of DRB1*08:11 in Native Americans, and DRB1*15:01 for the presence of DRB1*15:03 in African Americans or DRB1*15:06 in Asian donors. Discrepancy rate was 55%, 86%, 31%, 75%, and 13%, respectively. Utilizing the HLA typing date, race, and date an allele in question was described may provide a selection strategy leading to the consideration of additional unrelated donors for searching patients.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 21, 2014
- Source ID
- 10.1111/tan.12442
Entities
People
- G. Flickinger
- J. Dehn
- J. Kempenich
- M. Setterholm
Organizations
- Health Resources and Services Administration
- National Marrow Donor Program
- Office of Naval Research