Full gene HLA class I sequences of 79 novel and 519 mostly uncommon alleles from a large United States registry population
Abstract
HLA class I assignments were obtained at single genotype, G‐level resolution from 98 855 volunteers for an unrelated donor registry in the United States. In spite of the diverse ancestry of the volunteers, over 99% of the assignments at each locus are common. Within this population, 52 novel alleles differing in exons 2 and 3 are identified and characterized. Previously reported alleles with incomplete sequences in the IPD‐IMGT/HLA database (n = 519) were selected for full gene sequencing and, from this sampling, another 27 novel alleles are described.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 20, 2018
- Source ID
- 10.1111/tan.13377
Entities
People
- Ana Lazaro
- Bin Tu
- Carly Masaberg
- Carolyn Hurley
- Dannah Simbulan
- Elizabeth Enriquez
- Jennifer Gerfen
- Jennifer Ng
- Kanthi Kariyawasam
- Lihua Hou
- Lisa Xun
- Misti Persaud
- Ruyan Yang
- Xihan Qin
- Yi Xiao
Organizations
- Georgetown University
- Office of Naval Research