Common, intermediate and well‐documented HLA alleles in world populations: CIWD version 3.0.0
Abstract
A catalog of common, intermediate and well‐documented (CIWD) HLA‐A, ‐B, ‐C, ‐DRB1, ‐DRB3, ‐DRB4, ‐DRB5, ‐DQB1 and ‐DPB1 alleles has been compiled from over 8 million individuals using data from 20 unrelated hematopoietic stem cell volunteer donor registries. Individuals are divided into seven geographic/ancestral/ethnic groups and data are summarized for each group and for the total population. P (two‐field) and G group assignments are divided into one of four frequency categories: common (≥1 in 10 000), intermediate (≥1 in 100 000), well‐documented (≥5 occurrences) or not‐CIWD. Overall 26% of alleles in IPD‐IMGT/HLA version 3.31.0 at P group resolution fall into the three CIWD categories. The two‐field catalog includes 18% (n = 545) common, 17% (n = 513) intermediate, and 65% (n = 1997) well‐documented alleles. Full‐field allele frequency data are provided but are limited in value by the variations in resolution used by the registries. A recommended CIWD list is based on the most frequent category in the total or any of the seven geographic/ancestral/ethnic groups. Data are also provided so users can compile a catalog specific to the population groups that they serve. Comparisons are made to three previous CWD reports representing more limited population groups. This catalog, CIWD version 3.0.0, is a step closer to the collection of global HLA frequencies and to a clearer view of HLA diversity in the human population as a whole.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 31, 2020
- Source ID
- 10.1111/tan.13811
Entities
People
- Ahmed Alaskar
- Alexander H. Schmidt
- Ali H. Hajeer
- Anastasios Manolis
- Ankit Mathur
- Ashminder Kaur
- Betina S. Sorensen
- Carolyn Hurley
- Daniel Schefzyk
- Dunia Jawdat
- Grazia Nicoloso
- Heather Dunckley
- Irene Andersen
- Jan A. Hofmann
- Jane Kempenich
- Jason Dehn
- John Mavrommatis
- Jürgen Sauter
- Kim Wadsworth
- Latha Jagannathan
- Louise Cho
- Lucie Houdova
- Malgorzata Dudkiewicz
- Maria B. R. Cardozo
- Mats Bengtsson
- Mohsen Alzahrani
- Nezih Cereb
- Nicoletta Sacchi
- Nira Shriki
- Pablo Galarza
- Pavel Jindra
- Pawinee Kupatawintu
- Raewyn Fisher
- Rafi Freudenberger
- Reem Ameen
- Sigal Manor
- Tigran Torosian
- Tiina Linjama
Organizations
- DKMS Donor Center gGmbH
- Georgetown University
- Gift of Life Bone Marrow Foundation
- King Saud bin Abdulaziz University for Health Sciences
- National Marrow Donor Program
- Office of Naval Research
- University of West Bohemia
- Uppsala University