Towards programmable plant genetic circuits
Abstract
Synthetic biology enables the construction of genetic circuits with predictable gene functions in plants. Detailed quantitative descriptions of the transfer function or input–output function for genetic parts (promoters, 5′ and 3′ untranslated regions, etc.) are collected. These data are then used in computational simulations to determine their robustness and desired properties, thereby enabling the best components to be selected for experimental testing in plants. In addition, the process forms an iterative workflow which allows vast improvement to validated elements with sub‐optimal function. These processes enable computational functions such as digital logic in living plants and follow the pathway of technological advances which took us from vacuum tubes to cell phones.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 01, 2016
- Source ID
- 10.1111/tpj.13235
Entities
People
- Ashok Prasad
- June I. Medford
Organizations
- Colorado State University
- Defense Advanced Research Projects Agency
- Office of Naval Research