The bioequivalence of frozen plasma prepared from whole blood held overnight at room temperature compared to fresh‐frozen plasma prepared within eight hours of collection
Abstract
Overnight, room temperature hold of whole blood (WB) before leukoreduction and component processing offers significant logistic and cost advantages over WB processed within 8 hours. Plasma prepared from WB held at room temperature overnight (PF24RT24WB) may result in a degradation of plasma coagulation protein activities compared to plasma frozen within 8 hours of collection. In this study, we intended to evaluate the bioequivalence (BE) of PF24RT24WB prepared using a new WB collection, leukoreduction, and storage system compared to fresh‐frozen plasma (FFP) after 12 months of frozen storage.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 19, 2014
- Source ID
- 10.1111/trf.12864
Entities
People
- Alan H. Siegel
- John R Hess
- Jose A Cancelas
- Larry J. Dumont
- Lou Ann Maes
- Louise Herschel
- Majid Zia
- Neeta Rugg
- Pamela Whitley
- Zbigniew M. Szczepiorkowski
Organizations
- American Red Cross
- Geisel School of Medicine
- United States Army Medical Research and Development Command
- University of Cincinnati
- University of Washington