CO2‐dependent metabolic modulation in red blood cells stored under anaerobic conditions
Abstract
Anaerobic red blood cell (RBC) storage reduces oxidative damage, maintains adenosine triphosphate (ATP) and 2,3‐diphosphoglycerate (DPG) levels, and has superior 24‐hour recovery at 6 weeks compared to standard storage. This study will determine if removal of CO2 during O2 depletion by gas exchange may affect RBCs during anaerobic storage.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 19, 2015
- Source ID
- 10.1111/trf.13364
Entities
People
- Angelo D'Alessandro
- Larry J. Dumont
- Tatsuro Yoshida
- Zbigniew M. Szczepiorkowski
Organizations
- Dartmouth–Hitchcock Medical Center
- Geisel School of Medicine
- Istituto Superiore di Sanità
- Office of Small Business Innovation Research and Small Business Technology Transfer Programs
- University of Colorado