Temperature cycling during platelet cold storage improves in vivo recovery and survival in healthy volunteers
Abstract
Room temperature (RT) storage of platelets (PLTs) can support bacterial proliferation in contaminated units, which can lead to transfusion‐transmitted septic reactions. Cold temperature storage of PLTs could reduce bacterial proliferation but cold exposure produces activation‐like changes in PLTs and leads to their rapid clearance from circulation. Cold‐induced changes are reversible by warming and periodic rewarming during cold storage (temperature cycling [TC]) has been proposed to alleviate cold‐induced reduction in PLT circulation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 08, 2017
- Source ID
- 10.1111/trf.14392
Entities
People
- Andrey Skripchenko
- Chunrong Cheng
- Fei Xu
- Jaroslav G Vostal
- Johannah Ryan
- Michael Wellington
- Monique P Gelderman
- Pam Whitley
- Shalene Hanley
- Sherrie Sawyer
- Stephen J Wagner
- Ying Li
Organizations
- American Red Cross
- Center for Biologics Evaluation and Research
- United States Department of Defense