A whole genome approach for discovering the genetic basis of blood group antigens: independent confirmation for P1 and Xga
Abstract
Although P1 and Xga are known to be associated with the A4GALT and XG genes, respectively, the genetic basis of antigen expression has been elusive. Recent reports link both P1 and Xga expression with nucleotide changes in the promotor regions and with antigen‐negative phenotypes due to disruption of transcription factor binding.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Dec 28, 2018
- Source ID
- 10.1111/trf.15089
Entities
People
- Abigail Joseph
- Carrie L. Blout
- Christine Lomas‐francis
- Connie M Westhoff
- For The Medseq Project
- Helen H. Mah
- Manpreet Sidhu
- Maria Aguad
- Matthew S. Lebo
- Richard M Kaufman
- Robert C. Green
- Robin Smeland‐wagman
- Sunitha Vege
- Tiffany T. Nguyen
- William J Lane
Organizations
- Brigham and Women's Hospital
- Broad Institute
- Harvard Medical School
- National Human Genome Research Institute
- New York Blood Center
- United States Department of Defense