A prospective evaluation of thromboelastometry (ROTEM) to identify acute traumatic coagulopathy and predict massive transfusion in military trauma patients in Afghanistan
Abstract
Hemorrhage is the leading cause of preventable trauma‐related mortality and is frequently aggravated by acute traumatic coagulopathy (ATC). Viscoelastic tests such as rotational thromboelastometry (ROTEM) may improve identification and management of ATC. This study aimed to prospectively evaluate changes in ROTEM among combat casualties during the first 24 hours and compare the capabilities of our conventional clotting assay (international normalized ratio [INR], >1.2) to a proposed integrated ROTEM model (INR >1.2 with the addition of tissue factor pathway activation thromboelastometry [EXTEM] A5 ≤35 mm and/or EXTEM LI30 <97% on admission) to identify ATC and predict massive transfusion (MT).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 01, 2019
- Source ID
- 10.1111/trf.15176
Entities
People
- Andrew P Cap
- Chriselda Fedyk
- Christopher White
- Hana Kwan
- Heather Pidcoke
- Ian J Stewart
- Jared Cohen
- Jonathan Sosnov
- Kelly Heegard
- Kevin K Chung
- Thomas Scorer
- Zachary Wright
Organizations
- Aviano Air Base
- David Grant USAF Medical Center
- Keesler Air Force Base
- Uniformed Services University of the Health Sciences
- United States Army Medical Research and Development Command
- University of Bristol