Multiple GYPB gene deletions associated with the U− phenotype in those of African ancestry
Abstract
The MNS blood group system is defined by three homologous genes: GYPA, GYPB, and GYPE. GYPB encodes for glycophorin B (GPB) carrying S/s and the “universal” antigen U. RBCs of approximately 1% of individuals of African ancestry are U− due to absence of GPB. The U− phenotype has long been attributed to a deletion encompassing GYPB exons 2 to 5 and GYPE exon 1 (GYPB*01N).
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 30, 2020
- Source ID
- 10.1111/trf.15839
Entities
People
- Alba Sanchis‐juan
- Connie M Westhoff
- Helen H. Mah
- Jensyn Cone Sullivan
- Jonathan Stephens
- Judith Aeschlimann
- Maria Aguad
- Matthew S. Lebo
- Nicholas S. Gleadall
- Prathik K. Vijay Kumar
- Richard M Kaufman
- Robert C. Green
- Robin Smeland‐wagman
- Sunitha Vege
- Willem H. Ouwehand
- William J Lane
Organizations
- Brigham and Women's Hospital
- Broad Institute
- Doris Duke Charitable Foundation
- Harvard Medical School
- NHS Blood and Transplant
- National Human Genome Research Institute
- National Institute for Health and Care Research
- National Institutes of Health
- New York Blood Center
- United States Department of Defense
- University of Cambridge
- Wellcome Sanger Institute