Validation of a SCID mouse model for transfusion by concurrent comparison of circulation kinetics of human platelets, stored under various temperature conditions, between human volunteers and mice
Abstract
Initial evaluation of new platelet (PLT) products for transfusion includes a clinical study to determine in vivo recovery and survival of autologous radiolabeled PLTs in healthy volunteers. These studies are expensive and do not always produce the desired results. A validated animal model of human PLTs in vivo survival and recovery used pre‐clinically could reduce the risk of failing to advance product development.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 06, 2020
- Source ID
- 10.1111/trf.15953
Entities
People
- Andrey Skripchenko
- Chunrong Cheng
- Fei Xu
- Jaroslav G Vostal
- Johannah Ryan
- Monique P Gelderman
- Pamela Whitley
- Stephen J Wagner
- Ying Li
Organizations
- American Red Cross
- Food and Drug Administration
- United States Department of Defense