Safety profile of high molecular weight polymerized hemoglobins
Abstract
Hemoglobin (Hb)‐based oxygen (O2) carriers (HBOCs) are being developed as alternatives to red blood cells and blood when these products are unavailable. Clinical trials of previous HBOC generations revealed side effects, including hypertension and vasoconstriction, that were not observed in preclinical studies. Large molecular weight (MW) polymerized bovine Hb (PolybHb) represents a new class of HBOC with promising results. We evaluated the safety profile of PolybHb after an exchange transfusion (ET) in guinea pigs (GPs). This study compares changes in indices of cardiac, inflammatory, and organ function after ET with high (R‐state) and low (T‐state) O2 affinity PolybHb with high MW.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 26, 2020
- Source ID
- 10.1111/trf.16157
Entities
People
- Alexander T Williams
- Allyn M. Eaker
- Amanda N. Breton
- Andre F. Palmer
- Carlos J. Munoz
- Cynthia R Muller
- Pedro Cabrales
Organizations
- National Institutes of Health
- Ohio State University
- United States Department of Defense
- University of California, San Diego