Effects of radiation exposure and storage on the energy metabolome of platelets in whole blood
Abstract
Exposure to radiation through battlefield use of nuclear weapons, terrorist attacks or accidents at nuclear power plants is a current concern for the military. Beyond the risk of exposure to personnel is the intentional or accidental irradiation of our blood banking supply system. It is unknown how large doses of ionizing radiation affect storage of blood and blood products, including platelets. The major function of platelets is clot formation which includes aggregation, shape change, vesicle release, and fibrinogen attachment; these tasks require a significant amount of energy. Here, we determine whether the ionizing radiation effects the energy metabolome of platelets in storage.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 17, 2023
- Source ID
- 10.1111/trf.17332
Entities
People
- Barbara A Christy
- Daniel N. Darlington
- James A. Bynum
- Maryanne C. Herzig
- Sandra C. Becerra
Organizations
- Congressionally Directed Medical Research Programs
- Department of Surgery
- joint base