Metabolic effects of radiation on red blood cells from cold stored whole blood
Abstract
The risk of military and civilian radiation exposure is increasing, and determining the effects of exposure is a high priority. Irradiation of the nearby blood supply after a nuclear event may impede mobilization of blood products for resuscitation at a time of great need. RBCs are administered to patients with trauma and hemorrhage to transport and deliver oxygen and avoid tissue hypoxia. Here we determine the effects of ionizing radiation on the energy metabolome of RBCs isolated from cold stored whole blood to determine if their stability is compromised by radiation exposure.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 08, 2023
- Source ID
- 10.1111/trf.17345
Entities
People
- Barbara A Christy
- Daniel N. Darlington
- James A. Bynum
- Maryanne C. Herzig
- Sandra C. Becerra
Organizations
- Congressionally Directed Medical Research Programs
- University of Texas Health Science Center at San Antonio