Anti‐fibrinolytic agent tranexamic acid suppresses the endotoxin‐induced expression of Tnfα and Il1α genes in a plasmin‐independent manner
Abstract
Tranexamic acid (TXA) is widely used as an antifibrinolytic agent in hemorrhagic trauma patients. The beneficial effects of TXA exceed the suppression of blood loss and include the ability to decrease inflammation and edema. We found that TXA suppresses the release of mitochondrial DNA and enhances mitochondrial respiration. These results allude that TXA could operate through plasmin‐independent mechanisms. To address this hypothesis, we compared the effects of TXA on lipopolysaccharide (LPS)‐induced expression of proinflammatory cytokines in plasminogen (Plg) null and Plg heterozygous mice.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 25, 2023
- Source ID
- 10.1111/trf.17353
Entities
People
- Angus Fung
- Autumn Greene
- Damien Carter
- Doreen Kacer
- Eva Machnitzky
- Igor Prudovsky
- Joseph F. Rappold
Organizations
- United States Department of Defense