NOS1AP genetic variation is associated with impaired healing of diabetic foot ulcers and diminished response to healing of circulating stem/progenitor cells
Abstract
It is unclear why many with diabetes develop foot ulcers (DFU) and why some do not heal. It could be associated with genetic variation. We have previously shown that NOS1AP variation is associated with lower extremity amputation in those with diabetes and that circulating stem progenitor cell concentration (SPC) is associated with impaired foot ulcer healing in those with diabetes. The goal of this study was to determine if NOS1AP variation is associated with impaired wound healing and with SPC mobilization in those with DFU. In longitudinal cohort study we demonstrate that NOS1AP variants rs16849113 and rs19649113 are associated with impaired wound healing and with SPC mobilization in those with DFU. We believe that further study of NOS1AP is merited and that it NOS1AP might be associated with a functional impairment.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 01, 2017
- Source ID
- 10.1111/wrr.12564
Entities
People
- D. Scot Mala
- David J. Margolis
- Diana Woltereck
- Michael A. Troiano
- Michelle Hampton
- Ming Yang
- Nandita Mitra
- Ole Hoffstad
- Stephen R. Thom
- Steven Shannon
- Veena M. Bhopale
- Ziad Mirza
Organizations
- Greater Baltimore Medical Center
- Office of Naval Research
- Penn Presbyterian Medical Center
- Perelman School of Medicine at the University of Pennsylvania
- University of Maryland School of Medicine
- University of Pennsylvania