Glucose metabolism in pigs expressing human genes under an insulin promoter
Abstract
Xenotransplantation of porcine islets can reverse diabetes in non‐human primates. The remaining hurdles for clinical application include safe and effective T‐cell‐directed immunosuppression, but protection against the innate immune system and coagulation dysfunction may be more difficult to achieve. Islet‐targeted genetic manipulation of islet‐source pigs represents a powerful tool to protect against graft loss. However, whether these genetic alterations would impair islet function is unknown.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 10, 2014
- Source ID
- 10.1111/xen.12145
Entities
People
- Burcin Ekser
- Carol J. Phelps
- Cassandra Long
- David Ayares
- David K.C. Cooper
- Dirk Van Der Windt
- Frederico G. S. Toledo
- Hayoto Iwase
- Hidetaka Hara
- Martin Wijkstrom
- Massimo Trucco
- Rita Bottino
Organizations
- JDRF
- National Institutes of Health
- United States Department of Defense
- United Therapeutics
- University of Pittsburgh