Observations on hydronephrosis after pig kidney transplantation in baboons
Abstract
We have seen hydronephrosis (obstructive nephropathy) at necropsy in 3 of 11 (21%) genetically‐engineered pig kidneys that functioned in baboons for >36 days, even when the clinical and histopathological features of rejection were minimal. We briefly report one such case and illustrate the macroscopic and microscopic appearances of such a kidney and ureter. The causes of the observed changes remain uncertain. In our small experience, there seems to be no correlation between the development of hydronephrosis and (i) the surgical technique, (ii) the genotype of the pig, (iii) the length of the pig ureter, or (iv) the immunosuppressive and anti‐inflammatory therapy administered. We suggest that the distal ureteric thickening may be the result of an inflammatory response. In two cases, we resolved the problem by carrying out a secondary side‐to‐side anastomosis between the proximal pig ureter and the baboon bladder.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 25, 2022
- Source ID
- 10.1111/xen.12779
Entities
People
- Abhinav Humar
- Christophe Hansen‐estruch
- David Ayares
- David K.C. Cooper
- Devin E. Eckhoff
- Hidetaka Hara
- Jeremy B. Foote
- Mariyam Javed
- Mohamed H. Bikhet
Organizations
- United States Department of Defense
- United Therapeutics
- University of Alabama at Birmingham
- University of Pittsburgh