Semi-Adaptive Closed-Loop Control for Infusion of Medications With Transport Delay in Clinical Effects
Abstract
This paper presents a semi-adaptive closed-loop control approach to autonomous infusion of medications exhibiting significant transport delay in clinical effects. The basic idea of the approach is to enable stable adaptive control of medication infusion by (1) incorporating transport delay explicitly into control design by way of a Padé approximation while (2) facilitating linear parameterization of control design model by desensitization of nonlinearly parameterized cooperativity constant associated with pharmacodynamics (PD). A novel dynamic dose–response model for control design is presented, in which the cooperativity constant exerts zero influence on the model output in the steady-state. Then, an adaptive pole placement control (APPC) technique was employed to fulfill adaptive control design in the presence of nonminimum phase dynamics associated with the Padé approximation of transport delay. The controller was evaluated in silico using a case study of regulating a cardiovascular variable with a sedative under a wide range of transport delay and pharmacological profiles. The results suggest that adaptation of transport delay and pharmacological characteristics may be beneficial in achieving consistent and robust regulation of medication-elicited clinical effects.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 09, 2019
- Source ID
- 10.1115/1.4042686
Entities
People
- Chang-Sei Kim
- Guy A. Dumont
- Jin-Oh Hahn
- Steven T. Shipley
- Xin Jin
Organizations
- Chonnam National University
- Office of Naval Research
- University of British Columbia
- University of Maryland
- University of North Carolina