Improved base excision repair inhibition and bacteriophage Mu Gam protein yields C:G-to-T:A base editors with higher efficiency and product purity
Abstract
Probing base editing outcomes leads to new C:G to T:A base editors with greater efficiency and product purity, and fewer indels.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Aug 04, 2017
- Source ID
- 10.1126/sciadv.aao4774
Entities
People
- Ahmed H Badran
- Alexis Komor
- Amanda L. Waterbury
- David R. Liu
- Kevin T. Zhao
- Luke W. Koblan
- Michael S Packer
- Nicole M Gaudelli
- Y. Bill Kim
Organizations
- Broad Institute
- Harvard University
- Howard Hughes Medical Institute
- National Institute of Biomedical Imaging and Bioengineering
- National Institute of General Medical Sciences