A mouse model of 22q11.2 deletions: Molecular and behavioral signatures of Parkinson’s disease and schizophrenia

Abstract

22q11.2 deletions, a genetic risk for schizophrenia, could be susceptible to Parkinson’s disease through elevated expression of α-synuclein.

Document Details

Document Type
Pub Defense Publication
Publication Date
Aug 03, 2018
Source ID
10.1126/sciadv.aar6637

Entities

People

  • Akiko Sumitomo
  • Akira Sawa
  • Anne S. Bassett
  • Erik Boot
  • Frederick C. Nucifora Jr.
  • Kazuko Hirai
  • Kouta Horike
  • Nancy Butcher
  • Takeshi Sakurai
  • Toshifumi Tomoda

Organizations

  • Brain & Behavior Research Foundation
  • Canadian Institutes of Health Research
  • Centre for Addiction and Mental Health
  • Japan Society for the Promotion of Science
  • Johns Hopkins University
  • Maryland Stem Cell Research Fund
  • Office of the Director
  • Stanley Center for Peace and Security
  • United States Department of Defense
  • University of Toronto

Tags

Fields of Study

  • Biology
  • Psychology

Technology Areas

  • Biotechnology