PP2Cδ inhibits p300-mediated p53 acetylation via ATM/BRCA1 pathway to impede DNA damage response in breast cancer
Abstract
Aberrant PP2Cδ inhibits p300-mediated p53 acetylation and activation via the ATM/BRCA1 pathway, leading to cancer progression.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 11, 2019
- Source ID
- 10.1126/sciadv.aaw8417
Entities
People
- Donghui Zhu
- Guanglin Chen
- Jay Vadgama
- Jieqing Li
- Jonathan R. Pollack
- Ke Wu
- Qiao-Hong Chen
- Qiongyu Hao
- Qun Li
- Wei Cao
- Yahya Elshimali
- Yong Wu
Organizations
- California State University
- Charles R. Drew University of Medicine and Science
- Fudan University
- National Institutes of Health
- Stanford University
- Tongji University
- United States Department of Defense
- University of North Texas