LPA 1/3 overactivation induces neonatal posthemorrhagic hydrocephalus through ependymal loss and ciliary dysfunction
Abstract
LPA, a blood-borne signaling lipid, induces neonatal hydrocephalus by damaging ependymal cells through LPA 1/3 overactivation.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 11, 2019
- Source ID
- 10.1126/sciadv.aax2011
Entities
People
- Aaron J Frantz
- Grace A Kennedy
- Jerold Chun
- Nicole C Lummis
- Paloma Sánchez-pavón
- Victoria A Blaho
- Yasuyuki Kihara
Organizations
- American Heart Association
- National Heart, Lung, and Blood Institute
- National Institute of General Medical Sciences
- National Institute of Mental Health
- National Institute of Neurological Disorders and Stroke
- Sanford Burnham Prebys Medical Discovery Institute
- United States Department of Defense
- University of California, San Diego