Inhibition of IRF5 cellular activity with cell-penetrating peptides that target homodimerization

Abstract

The rational targeting of a transcription factor, interferon regulatory factor 5 (IRF5), inhibits downstream functions.

Document Details

• Document Type: Pub Defense Publication
• Publication Date: May 15, 2020
• Source ID: 10.1126/sciadv.aay1057

Entities

People

• Ann F. Hoffman
• Betsy J Barnes
• Bharati Matta
• Charles A Wartchow
• Cherrie D. Thompson
• Chia-chi Sun
• Dan Li
• David R. Bolin
• Dinesh Srinivasan
• Francesca Milletti
• G. Lu
• Gang Chen
• Hong Qian
• Jaspreet Banga
• Jin Qiu
• Julie A DeMartino
• Kuo-Sen Huang
• Lena Liang
• Margaret LaPan
• Michelle Downing
• Nader Fotouhi
• Qin Guo
• Satwant Narula
• Seng-lai Tan
• Shannon Hamilton
• Su Song
• Yajuan Gu Qin

Organizations

• Alliance for Lupus Research
• Donald and Barbara Zucker School of Medicine at Hofstra/Northwell
• EMD Serono (United States)
• National Institute of Arthritis and Musculoskeletal and Skin Diseases
• The Feinstein Institute for Medical Research
• United States Department of Defense