Aneuploidy and a deregulated DNA damage response suggest haploinsufficiency in breast tissues of BRCA2 mutation carriers
Abstract
Normal breast epithelia from BRCA2 mutation carriers display DNA damage and attenuated checkpoint responses.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 31, 2020
- Source ID
- 10.1126/sciadv.aay2611
Entities
People
- Adam Langenbucher
- Andrea Desmond
- Angelika Amon
- Elena Zarcaro
- Hiranmayi Ravichandran
- Kenneth N Ross
- Leif W Ellisen
- Michael Lawrence
- Michelle C. Specht
- Mihriban Karaayvaz
- Murat Yıldırım
- Ravindra Mylvaganam
- Rebecca E Silberman
- Sridhar Ramaswamy
- Srinivas Vinod Saladi
- Varunika Vivekanandan
Organizations
- Harvard Medical School
- Howard Hughes Medical Institute
- Massachusetts Eye and Ear Infirmary
- Massachusetts General Hospital
- Massachusetts Institute of Technology
- Susan G. Komen for the Cure