The Huntingtin-interacting protein SETD2/HYPB is an actin lysine methyltransferase
Abstract
SETD2 regulates actin dynamics and cell migration via methylation of actin at Lys 68 in a cellular complex containing Huntingtin.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 02, 2020
- Source ID
- 10.1126/sciadv.abb7854
Entities
People
- Bryan A. Millis
- Cheryl Lyn Walker
- Durga Nand Tripathi
- Frank M. Mason
- In Young Park
- Kristen J. Verhey
- Matthew J Tyska
- Menuka Karki
- Michael A Cianfrocco
- Rahul K Jangid
- Riyad N H Seervai
- Ruhee Dere
- Sarah Kearns
- Sung Yun Jung
- W. Kimryn Rathmell
Organizations
- American Heart Association
- Baylor College of Medicine
- Cancer Prevention and Research Institute of Texas
- John Templeton Foundation
- National Cancer Institute
- National Institute of Environmental Health Sciences
- National Institutes of Health
- United States Department of Defense
- University of Michigan
- Vanderbilt University