1-Methylnicotinamide is an immune regulatory metabolite in human ovarian cancer

Abstract

MNA contributes to the immune suppression of T cells and represents a potential immunotherapy target to treat human cancer.

Document Details

Document Type
Pub Defense Publication
Publication Date
Jan 22, 2021
Source ID
10.1126/sciadv.abe1174

Entities

People

  • Abigail E. Ellis
  • Bertrand Allard
  • Brad H Nelson
  • Brenna Pauly
  • Elaine Y. Liu
  • Gillian Carleton
  • John Stagg
  • Julian J. Lum
  • Julian Smazynski
  • Kelsey S. Williams
  • Lauren G. Zacharias
  • Marisa K. Kilgour
  • Peter H. Watson
  • Phineas T. Hamilton
  • Ralph J DeBerardinis
  • Russell G Jones
  • Ryan D. Sheldon
  • Sarah Keyes
  • Sarah Macpherson

Organizations

  • BC Cancer Agency
  • BC Cancer Foundation
  • Canada Foundation for Innovation
  • Canadian Institutes of Health Research
  • Institut du cancer de Montréal
  • United States Department of Defense
  • University of British Columbia
  • University of Texas Southwestern Medical Center
  • University of Victoria
  • Université de Montréal
  • Van Andel Institute

Tags

Fields of Study

  • Biology
  • Chemistry

Technology Areas

  • Biotechnology
  • Biotechnology - Cancer Biotech