Posttranslational regulation of FOXA1 by Polycomb and BUB3/USP7 deubiquitin complex in prostate cancer
Abstract
FOXA1 is a nonhistone substrate of EZH2, promoting cell growth and sensitizing some prostate cancer to enzymatic EZH2 inhibitors.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 09, 2021
- Source ID
- 10.1126/sciadv.abe2261
Entities
People
- Chunming Guo
- David W Goodrich
- Deyu Fang
- Fang Wang
- Jindan Yu
- John D. Crispino
- Jonathan C. Zhao
- Jung Kim
- Ka-wing Fong
- Kristine Wadosky
- Lourdes T Brea
- Panagiotis Ntziachristos
- Sarki A. Abdulkadir
- Su H. Park
- Xiaodong Lü
- Xin Liu
- Xue Li
- Yong Wan
- Yongik Lee
Organizations
- American Cancer Society
- Harvard Medical School
- National Cancer Institute
- Northwestern University
- Office of the Director
- Prostate Cancer Foundation
- Roswell Park Comprehensive Cancer Center
- St. Jude Children's Research Hospital
- University of Texas Southwestern Medical Center