Ciliopathy protein HYLS1 coordinates the biogenesis and signaling of primary cilia by activating the ciliary lipid kinase PIPKIγ
Abstract
HYLS1 regulates the ciliary phosphoinositide and hedgehog pathways, implicating a novel pathogenic mechanism for HLS syndrome.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 25, 2021
- Source ID
- 10.1126/sciadv.abe3401
Entities
People
- Brian A. Davies
- Chuan Chen
- David J. Katzmann
- Jinghua Hu
- Kun Ling
- Peter C. Harris
- Qingwen Xu
- Yan Huang
- Yuxia Zhang
Organizations
- Mayo Clinic
- National Institute of Diabetes and Digestive and Kidney Diseases
- National Institute of General Medical Sciences
- National Institutes of Health
- United States Department of Defense