Nsp1 protein of SARS-CoV-2 disrupts the mRNA export machinery to inhibit host gene expression
Abstract
SARS-CoV-2 Nsp1 protein binds the mRNA export receptor NXF1-NXT1 to inhibit nuclear export of mRNAs and promote infection.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Feb 05, 2021
- Source ID
- 10.1126/sciadv.abe7386
Entities
People
- Adolfo García-Sastre
- Anil Kumar
- Beatriz M A Fontoura
- Boning Gao
- Christopher Ptak
- Hualin Zhong
- Ishmael Dehghan
- John Minna
- Ke Zhang
- Lisa Miorin
- Matthew Esparza
- Richard W. Wozniak
- Shengyan Gao
- Tadashi Makio
- Thomas Kehrer
- Tom C. Hobman
- Yi Ren
- Yihu Xie
- Zhijian Chen
Organizations
- Canadian Institutes of Health Research
- Cancer Prevention and Research Institute of Texas
- Hunter College
- Icahn School of Medicine at Mount Sinai
- National Cancer Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of General Medical Sciences
- University of Alberta
- University of Texas Southwestern Medical Center
- University of Texas at Austin
- Vanderbilt University