Elevated type I interferon responses potentiate metabolic dysfunction, inflammation, and accelerated aging in mtDNA mutator mice
Abstract
IFN-I–NRF2 signaling imbalances drive immunometabolic dysfunction, inflammation, and premature aging in POLG mutator mice.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- May 28, 2021
- Source ID
- 10.1126/sciadv.abe7548
Entities
People
- A. Phillip West
- Camila Guerra Martinez
- Carl W. Tong
- Christine E. Birdwell
- Joshua D. Bryant
- Laura Ciaccia West
- Robert O Watson
- Samantha L Bell
- Sylvia Torres-Odio
- Yuanjiu Lei
Organizations
- National Heart, Lung, and Blood Institute
- National Institute of Allergy and Infectious Diseases
- National Institute of Environmental Health Sciences
- United States Department of Defense