Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking
Abstract
Massive fragment screening effort provides a foundation for the development of macrodomain inhibitors as novel antiviral agents.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 16, 2021
- Source ID
- 10.1126/sciadv.abf8711
Entities
People
- Ailsa Powell
- Aina E Cohen
- Alan Ashworth
- Alexandre Dias
- Alexei S Soares
- Alice Douangamath
- Anthony Aimon
- Aye C Thwin
- Brian K. Shoichet
- Clyde A Smith
- Daren Fearon
- Dominique H. Smith
- Frank von Delft
- G. Meigs
- Galen J Correy
- Gregory E Merz
- Huong Q Tran
- Iris D Young
- Ishan Deshpande
- Ivan Ahel
- James M Bennett
- James M Holton
- James S Fraser
- Jason E Gestwicki
- Jennifer L Wierman
- Jessica K Peters
- Johannes Gregor Matthias Rack
- John J Irwin
- José Brandão-Neto
- Justin T Biel
- Kang Zhu
- Louise Dunnett
- Luan Carvalho Martins
- Marion Schuller
- Martin R Fuchs
- Matteo P Ferla
- Michael C Thompson
- Michael G. Johnson
- Michelle Moritz
- Nadia Herrera
- Natalia Jura
- Oleg Fedorov
- Peter O'Brien
- Qcrg Structural Biology Consortium
- Rachael Elaine Skyner
- Roberto Efrain Diaz
- Silvia Russi
- Stefan Gahbauer
- Taiasean Wu
- Tobias Krojer
- Tristan W Owens
- Tyler Gorrie-Stone
- Ursula Schulze-Gahmen
- Victor L Rangel
Organizations
- Biotechnology and Biological Sciences Research Council
- Brookhaven National Laboratory
- Cancer Research UK
- Defense Advanced Research Projects Agency
- Diamond Light Source
- Federal University of Minas Gerais
- Lawrence Berkeley National Laboratory
- National Institutes of Health
- National Science Foundation
- Stanford Synchrotron Radiation Lightsource
- University of California
- University of California, San Francisco
- University of Johannesburg
- University of Oxford
- University of São Paulo
- University of York
- Wellcome