Helicobacter pylori SabA Adhesin in Persistent Infection and Chronic Inflammation
Abstract
Helicobacter pylori adherence in the human gastric mucosa involves specific bacterial adhesins and cognate host receptors. Here, we identify sialyl-dimeric-Lewis x glycosphingolipid as a receptor for H . pylori and show that H . pylori infection induced formation of sialyl-Lewis x antigens in gastric epithelium in humans and in a Rhesus monkey. The corresponding sialic acid–binding adhesin (SabA) was isolated with the “retagging” method, and the underlying sabA gene (JHP662/HP0725) was identified. The ability of many H . pylori strains to adhere to sialylated glycoconjugates expressed during chronic inflammation might thus contribute to virulence and the extraordinary chronicity of H . pylori infection.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 26, 2002
- Source ID
- 10.1126/science.1069076
Entities
People
- Andre Dubois
- Anna Arnqvist
- Berit Sondén
- Bertil B. Lundskog
- Christoffer Petersson
- Dangeruta Kersulyte
- Douglas E. Berg
- Farzad O. Olfat
- Frank Lindh
- Jafar Mahdavi
- Jonas Ångström
- Karl-anders Karlsson
- Karl-eric Magnusson
- Lennart Hammarström
- Lina Forsberg
- Marina Hurtig
- Niamh Roche
- Siiri Altraja
- Susann Teneberg
- Thomas Borén
- Thomas Larsson
- Thomas Norberg
- Torkel Wadström
Organizations
- Karolinska Institutet
- Linköping University
- Lund University
- Public Health Agency of Sweden
- Swedish University of Agricultural Sciences
- Umeå University
- Uniformed Services University of the Health Sciences
- University of Gothenburg
- University of Tartu
- Washington University School of Medicine