Discovery of Gene Function by Expression Profiling of the Malaria Parasite Life Cycle
Abstract
The completion of the genome sequence for Plasmodium falciparum , the species responsible for most malaria human deaths, has the potential to reveal hundreds of new drug targets and proteins involved in pathogenesis. However, only ∼35% of the genes code for proteins with an identifiable function. The absence of routine genetic tools for studying Plasmodium parasites suggests that this number is unlikely to change quickly if conventional serial methods are used to characterize encoded proteins. Here, we use a high-density oligonucleotide array to generate expression profiles of human and mosquito stages of the malaria parasite's life cycle. Genes with highly correlated levels and temporal patterns of expression were often involved in similar functions or cellular processes.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 12, 2003
- Source ID
- 10.1126/science.1087025
Entities
People
- Anthony A. Holder
- Daniel J. Carucci
- Elizabeth Winzeler
- J. David Haynes
- J. Kathleen Moch
- Karine G. Le Roch
- Muni Grainger
- Patricia De La Vega
- Peter L. Blair
- Serge Batalov
- Yingyao Zhou
Organizations
- National Institute for Medical Research
- Naval Medical Research Center
- Novartis
- Scripps Research
- Walter Reed Army Institute of Research