Influence of HLA-C Expression Level on HIV Control
Abstract
Multiple genome-wide association studies have revealed that human leukocyte antigen (HLA) genes of the major histocompatibility complex locus have the strongest impact on HIV. In particular, a single-nucleotide polymorphism 35 base pairs upstream of HLA-C shows significant association with viral load and protection against HIV. How HLA-C mediates these effects is unknown. Apps et al. (p. 87 ) now demonstrate that increasing surface expression of HLA-C is associated with reduced viral load and reduced rate of progression to low CD4 + T cell counts in African and European Americans. High HLA-C expression likely promoted improved HIV control through a more effective cytotoxic CD8 + T cell response. In contrast to HIV infection, high HLA-C expression was associated with a higher risk of the inflammatory bowel disease, Crohn's disease.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Apr 05, 2013
- Source ID
- 10.1126/science.1232685
Entities
People
- Amy Weintrob
- Ashley Moffett
- Bruce D Walker
- Chanson J. Brumme
- David Heckerman
- Florencia Pereyra
- George T. Nelson
- Greg Q. Del Prete
- Gregory D. Kirk
- Haoyan Chen
- Jacques Fellay
- James J. Goedert
- Jeffrey D. Lifson
- Jingyuan Fang
- Jonathan M. Carlson
- Judy L. Stein
- Kelly A. Soderberg
- M Anthony Moody
- Mary Carrington
- Mina John
- Nelson Michael
- Paul Mclaren
- Philip Goulder
- Rasmi Thomas
- Richard Apps
- Ronald Bosch
- Simon A. Mallal
- Steven G Deeks
- Steven Wolinsky
- Susan Buchbinder
- Thomas N. Denny
- Wilson Liao
- Xiaojiang Gao
- Xue Zeng
- Ying Qi
- Yuko Yuki
- Zabrina L. Brumme
Organizations
- Duke University
- Guang’anmen Hospital
- Johns Hopkins University
- Lausanne University Hospital
- Massachusetts Institute of Technology
- Microsoft
- Murdoch University
- National Cancer Institute
- Northwestern University
- Science Applications International Corporation
- Shanghai Jiao Tong University
- Simon Fraser University
- Uniformed Services University of the Health Sciences
- United States Military HIV Research Program
- University of California
- University of Cambridge
- University of KwaZulu-Natal
- University of Oxford