Protection Against Malaria by Intravenous Immunization with a Nonreplicating Sporozoite Vaccine
Abstract
Each year, hundreds of millions of people are infected with Plasmodium falciparum , the mosquito-borne parasite that causes malaria. A preventative vaccine is greatly needed. Seder et al. (p. 1359 , published online 8 August; see the Perspective by Good ) now report the results from a phase I clinical trial where subjects were immunized intravenously with a whole, attenuated sporozoite vaccine. Three of 9 subjects who received four doses and zero of 6 subjects who received five doses of the vaccine went on to develop malaria after controlled malaria infection. Both antibody titers and cellular immune responses correlated positively with the dose of vaccine received, suggesting that both arms of the adaptive immune response may have participated in the observed protection.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Sep 20, 2013
- Source ID
- 10.1126/science.1241800
Entities
People
- Abraham G. Eappen
- Adam J. Ruben
- Adam Richman
- Aderonke Awe
- Anita Manoj
- Anna Lau
- Anusha Gunasekera
- Arnel Belmonte
- Asha Patil
- Awalludin Sutamihardja
- B. Kim Lee Sim
- Barney S. Graham
- Bing Jiang
- Brandon Wilson
- Brenda Larkin
- Cassandra Digiovanni
- Chinnamma Chakiath
- Christopher Plowe
- Cynthia S. Hendel
- Debbie Padilla
- Enni Fomumbod
- Eric R. James
- Esteban N. Abot
- Esther C. Williams
- Floreliz H. Mendoza
- Galina Yamshchikov
- Gary A. Fahle
- Harini Ganeshan
- Hayley Loblein
- Hope Decederfelt
- Ingelise J. Gordon
- Iris Pittman
- Jack Komisar
- James Inglese
- James Overby
- Jamie G. Saunders
- Jason H. Richardson
- Jeffery Brocious
- Jillian Mitchell
- Jittawadee Murphy
- Joseph Casazza
- Judith E. Epstein
- Judith Starling
- Julie E. Ledgerwood
- Kathryn L. Zephir
- Kavita Tewari
- Keith A. Nelson
- Kirsten E. Lyke
- Lachonne Stanford
- Lasonji A. Holman
- Laura Novik
- Lee-jah Chang
- Lixin Gao
- Ly Diep
- Margaret Kemp
- Maria Belmonte
- Maria Burgos Florez
- Maria Socorro Orozco
- Mario Roederer
- Martha C. Nason
- Martha Sedegah
- Mary E. Enama
- Mary King
- Matthew Adams
- Matthew B. Laurens
- Meghan Kunchai
- Minglin Li
- Natasha Kc
- Nicole Luongo
- Nina Berkowitz
- Olga Vasilenko
- Pamela J. M. Costner
- Patricia Dranchak
- Pernell Williams
- Peter F. Billingsley
- Phyllis Zaia Renehan
- Richard E. Stafford
- Richard Fan
- Robert A Seder
- Robert T. Bailer
- Rui Xu
- Sandra Sitar
- Sarah H. Plummer
- Sharina Reyes
- Silas A. Davidson
- Soundarapandian Velmurugan
- Stella Antonara
- Stephen L. Hoffman
- Steve Matheny
- Sumana Chakravarty
- Tanya Clarke
- Tao Li
- The Vrc 312 Study Team
- Thomas L. Richie
- Tony Jun Huang
- Tooba Murshedkar
- Uzma N. Sarwar
- Virak Pich
- Yeab Getachew
- Yingda Wen
- Yonas Abebe
Organizations
- Howard Hughes Medical Institute
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- Naval Medical Research Center
- Sanaria
- University of Maryland
- Vaccine Research Center
- Walter Reed Army Institute of Research