Lassa virus entry requires a trigger-induced receptor switch
Abstract
Lassa virus, which spreads from rodents to humans, infecting about half a million people every year, can lead to deadly hemorrhagic fever. Like many viruses, Lassa virus binds to cell surface receptors. Jae et al. now show that to enter a cell, the virus requires a second receptor, this one inside the infected cell. This requirement sheds light on the “enigmatic resistance” of bird cells to Lassa virus observed three decades ago. Although bird cells have the cell surface receptor, the intracellular receptor cannot bind the virus, stopping it in its tracks.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 27, 2014
- Source ID
- 10.1126/science.1252480
Entities
People
- Ana I. Kuehne
- Andrew S Herbert
- Ariel S Wirchnianski
- Hans Janssen
- John M Dye
- Lucas T. Jae
- Markus Damme
- Matthijs Raaben
- Paul Saftig
- Sarah H. Stubbs
- Sean P. Whelan
- Thijn Brummelkamp
- Timothy K. Soh
Organizations
- Austrian Academy of Sciences
- Harvard Medical School
- NKI
- United States Army Medical Research Institute of Infectious Diseases