An interactive reference framework for modeling a dynamic immune system
Abstract
Multiple characteristics of individual cells define cell types and their physiological states. Spitzer et al. quantitated the abundance of 39 different cell surface proteins or transcription factors on individual cells of the mouse immune system. They used these measurements to create a map that clustered similar individual cells into groups corresponding to cell type and function. Their extensible experimental platform will allow the inclusion of other data types and data from independent laboratories.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 10, 2015
- Source ID
- 10.1126/science.1259425
Entities
People
- Andrew N. Hotson
- Edgar G. Engleman
- Eli R. Zunder
- Gabriela K Fragiadakis
- Garry P. Nolan
- Matthew H Spitzer
- Nupur Bhattacharya
- Pier Federico Gherardini
- Rachel Finck
- Robert T. Yuan
- Sean C Bendall
- Wendy J. Fantl
- Yaron Carmi
Organizations
- California Institute for Regenerative Medicine
- Damon Runyon Cancer Research Foundation
- European Commission
- Food and Drug Administration
- Gates Foundation
- Howard Hughes Medical Institute
- National Institute of Allergy and Infectious Diseases
- National Institutes of Health
- Stanford University
- United States Department of Defense