Differential regulation of mTORC1 by leucine and glutamine
Abstract
The protein kinase complex mTORC1 regulates growth and metabolism, and its activity is controlled in response to the abundance of cellular amino acids. Jewell et al. report that control of mTORC1 in response to glutamine does not require the Rag guanosine triphosphatase (GTPase) implicated in the sensing of other amino acids such as leucine (see the Perspective by Abraham). For sensing of glutamine, another GTPase, Arf1, was required. Distinct mechanisms thus appear to couple various amino acids to signaling by the mTORC1 complex.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jan 09, 2015
- Source ID
- 10.1126/science.1259472
Entities
People
- Fa-xing Yu
- Hyun Woo Park
- Jenna L. Jewell
- Kun-liang Guan
- Ryan C. Russell
- Steven W. Plouffe
- Vincent S. Tagliabracci
- Young Chul Kim
Organizations
- Canadian Institutes of Health Research
- Fudan University
- Hartwell Foundation
- National Institutes of Health
- United States Department of Defense
- University of California, San Diego