A protein fold switch joins the circadian oscillator to clock output in cyanobacteria
Abstract
Circadian clocks keep organisms in synch with such daily cycles as illumination, activity, and food availability. The circadian clock in cyanobacteria has the necessary 24-hour period despite its three component proteins having biochemical activities that occur on a much faster time scale. Abe et al. focused on the cyanobacterial clock component KaiC, an adenosine triphosphatase (ATPase) that can autophosphorylate and autodephosphorylate. The slow ATPase activity of KaiC, which is linked to a peptide isomerisation, provided the slow kinetics that set the speed of the 24-hour clock. Chang et al. found that another clock component, KaiB, also has slow changes in its protein conformation that help to set the oscillation period of the clock and its signaling output.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jul 17, 2015
- Source ID
- 10.1126/science.1260031
Entities
People
- Andy LiWang
- Connie Phong
- David Lee
- Jenny Lin
- Joseph S. Boyd
- Li Zhang
- Michael J. Rust
- R. David Britt
- Roger Tseng
- Shannon Kang
- Sheng Li
- Susan E Cohen
- Susan Golden
- William K. Myers
- Yong-Gang Chang
- Yong-ick Kim
- Yvonne Lee
Organizations
- Air Force Office of Scientific Research
- American Cancer Society
- Army Research Office
- National Institutes of Health
- National Science Foundation
- University of California
- University of California, San Diego
- University of Chicago