Wireless magnetothermal deep brain stimulation
Abstract
Current techniques to stimulate regions inside the brain need a permanently implanted wire or an optical fiber. Working in mice, Chen et al. developed a method to overcome this problem (see the Perspective by Temel and Jahanshahi). They introduced heat-sensitive capsaicin receptors into nerve cells and then injected magnetic nanoparticles into specific brain regions. The nanoparticles could be heated by external alternating magnetic fields, which activated the ion channel–expressing neurons. Thus, cellular signaling deep inside the brain can be controlled remotely without permanent implants.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Mar 27, 2015
- Source ID
- 10.1126/science.1261821
Entities
People
- Alan Mohr
- Gabriela Romero
- Michael G. Christiansen
- Polina Anikeeva
- Ritchie Chen
Organizations
- Defense Advanced Research Projects Agency
- Massachusetts Institute of Technology
- McGovern Institute for Brain Research