Protection Against Cutaneous Leishmaniasis Resulting from Bites of Uninfected Sand Flies
Abstract
Despite the fact that Leishmania are transmitted exclusively by sand flies, none of the experimental models of leishmaniasis have established infection via sand fly bites. Here we describe a reproducible murine model of Leishmania major infection transmitted by Phlebotomus papatasi . Prior exposure of mice to bites of uninfected sand flies conferred powerful protection against Leishmania major that was associated with a strong delayed-type hypersensitivity response and with interferon-γ production at the site of parasite delivery. These results have important implications for the epidemiology of cutaneous leishmaniasis and suggest a vaccination strategy against this and possibly other vector-borne diseases.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Nov 17, 2000
- Source ID
- 10.1126/science.290.5495.1351
Entities
People
- David Sacks
- Edgar Rowton
- Govind Modi
- Shaden Kamhawi
- Yasmine Belkaid
Organizations
- National Institutes of Health
- Walter Reed Army Institute of Research