Identification of an oncogenic RAB protein
Abstract
Healthy cells are like skilled air traffic controllers. They continually move proteins to and from the cellular destinations where they are needed, usually without mishap, through an elaborate system of endomembranes. Wheeler et al. show that a glitch in the traffic control system can help propel a cell toward malignancy (see the Perspective by Ferguson). RAB35, a protein previously implicated in endomembrane trafficking, is a key regulator of a well-known oncogenic signaling pathway. Mutations in RAB35 found in certain human tumors aberrantly activate this pathway and cause mislocalization of a factor that promotes cell growth.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Oct 09, 2015
- Source ID
- 10.1126/science.aaa4903
Entities
People
- Charles Sawyers
- David E Root
- David M. Sabatini
- Douglas B. Wheeler
- Roberto Zoncu
Organizations
- Broad Institute
- Howard Hughes Medical Institute
- Massachusetts Institute of Technology
- Memorial Sloan Kettering Cancer Center
- National Institutes of Health
- United States Department of Defense
- University of California, Berkeley
- Weill Cornell Medicine
- Whitehead Institute