Design of ordered two-dimensional arrays mediated by noncovalent protein-protein interfaces
Abstract
DNA has been used as a nano building material since the 1980s. Protein nanostructures have the potential to give greater geometric control and shape variability. Gonen et al. describe the computational design of proteins that self-assemble into two-dimensional arrays. These programmable protein lattices should enable new approaches in biomolecular structure determination and molecular sensing.
Document Details
- Document Type
- Pub Defense Publication
- Publication Date
- Jun 19, 2015
- Source ID
- 10.1126/science.aaa9897
Entities
People
- David Baker
- Frank DiMaio
- Shane Gonen
- Tamir Gonen
Organizations
- Air Force Office of Scientific Research
- Defense Threat Reduction Agency
- Howard Hughes Medical Institute
- University of Washington